Host characteristics predict outcome among adult patients admitted by severe acute respiratory infection

Autores/as

  • Alberto Fica Cubillos Hospital Base Valdivia
  • Francisco Pinto Francisco Pinto, Servicio de Infectología, Hospital Militar de Santiago. Av. Fernando Castillo Velasco 9100, La Reina, Santiago
  • Viviana Sotomayor Master in Public Health, Departamento de Epidemiología, Ministerio de Salud, Mac Iver 541, Santiago
  • Rodrigo Fasce Bachelor in Biochemistry, Subdepartamento de Enfermedades Virales, Instituto de Salud Pública de Chile. Av. Marathon 1000, Ñuñoa, Santiago
  • Winston Andrade Biologist, Ph.D. Subdepartamento de Enfermedades Virales, Instituto de Salud Pública de Chile. Av. Marathon 1000, Ñuñoa, Santiago
  • Jeannette Dabanch Servicio de Infectología, Hospital Militar de Santiago. Av. Fernando Castillo Velasco 9100, La Reina, Santiago
  • Andres Soto Servicio de Infectología, Hospital Militar de Santiago. Av. Fernando Castillo Velasco 9100, La Reina, Santiago
  • Vjera Triantafilo Laboratorio Central, Hospital Militar de Santiago. Av. Fernando Castillo Velasco 9100, La Reina, Santiago

Palabras clave:

Bedridden Persons, Frail Elderly, Mortality, Respiratory Tract Infections, Virus Diseases

Resumen

Background: Except for influenza pandemics, different observational studies have failed to demonstrate differences in mortality between various etiologies in adult patients hospitalized for respiratory infections. Aim: To compare clinical and mortality differences between different viral pathogens associated with severe acute respiratory infections (SARI) in hospitalized adults. Material and methods: One-year prospective study in a sentinel center. We included 132 patients with SARI hospitalized for any of the nine viruses under study by PCR. Clinical variables were compared, excluding cases of coinfection. Results: A viral coinfection was identified in 12% and influenza infection in 56% of cases. Eighty percent of patients were aged ? 65 years, with a high frequency of comorbidities, 27% were bedridden. Twenty four percent were admitted to critical care units, 20% required ventilatory assistance and 16% died. Cases occurred throughout the year, with an expected seasonal peak between autumn and spring and a predominance of infections not associated with influenza during summer months. In the multivariate analysis, only being bedridden was significantly associated with mortality at discharge (Odds ratio 23.46; 95% confidence intervals 3.33-165.12, p < 0.01), without association with age, comorbidity, viral pathogen involved, laboratory parameters, clinical presentation or CURB65 score. No major clinical dissimilarities were found between different viral pathogens. Conclusions: In our series of patients, mostly elderly, only bedridden status was significantly associated with mortality at discharge in patients hospitalized for SARI. Viral pathogens were not relevant.

Publicado

2019-07-19

Cómo citar

Fica Cubillos, A., Pinto, F., Sotomayor, V., Fasce, R., Andrade, W., Dabanch, J., Soto, A., & Triantafilo, V. (2019). Host characteristics predict outcome among adult patients admitted by severe acute respiratory infection. Revista Médica De Chile, 147(7). Recuperado a partir de https://www.revistamedicadechile.cl/index.php/rmedica/article/view/7441

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